Synonyms: LB100
Compound class:
Synthetic organic
Comment: LB-100 is a small molecule inhibitor of protein phosphatase 2A (PP2A) [3]. PP2A is a pivotal cellular switch that controls important events that impinge on cellular survival and death, such as cell cycle, apoptosis, and autophagy. PP2A acts on kinase substrates in a number of critical signal transduction pathways (including MAPK, Wnt, PI3K, NF&kappB, PKC, and Ca2+/calmodulin-dependent signalling pathways). PP2A is a validated oncology target. Studies have shown that LB-100 has anti-tumour activity [2] and can sensitise pancreatic cancer to chemotherapy [1] and radiotherapy [3].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(1R,4S)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid |
Synonyms |
LB100 |
Database Links | |
CAS Registry No. | 1632032-53-1 (source: ChemIDplus) |
ChEMBL Ligand | CHEMBL4297300 |
GtoPdb PubChem SID | 434122166 |
PubChem CID | 45101433 |
Search Google for chemical match using the InChIKey | JUQMLSGOTNKJKI-IZUQBHJASA-N |
Search Google for chemicals with the same backbone | JUQMLSGOTNKJKI |
UniChem Compound Search for chemical match using the InChIKey | JUQMLSGOTNKJKI-IZUQBHJASA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JUQMLSGOTNKJKI-IZUQBHJASA-N |