Synonyms: example 26 [WO2015037939A1] | example I-26 [WO2015037939A1]
Compound class:
Synthetic organic
Comment: This compound is one of the phthalazinone derivatives claimed as poly(ADP-ribose) polymerase (PARP) inhibitors in Ildong Pharmaceutical's patent WO2015037939A1, that were designed for antineoplastic potential [1]. The chemical structure matches that submitted to the WHO for the INN venadaparib. We have added its interaction data to PARP1. A potential Ildong internal code is IDX-1197, which is described by the NCI Drug Dictionary as an orally administered, PARP1/2 selective inhibitor, and this entry associates IDX-1197 with an earlier synonym, NOV140101. As of August 2020, there is nothing in the published literature to confirm these structure>code associations.
Pharmacological and biological activity of IDX-1197 is outlined in Abstract A106; AACR-NCI-EORTC International Conference (Oct 2017). IDX-1197 is in Phase 1/2 clinical trial in solid tumours with confirmed mutations in homologous recombination repair genes (NCT04174716). ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-[[3-[3-[(cyclopropylamino)methyl]azetidine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one |
International Nonproprietary Names ![]() |
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INN number | INN |
11225 | venadaparib |
Synonyms ![]() |
example 26 [WO2015037939A1] | example I-26 [WO2015037939A1] |
Database Links ![]() |
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CAS Registry No. | 1681017-83-3 (source: WHO INN record) |
GtoPdb PubChem SID | 434122244 |
PubChem CID | 117955898 |
Search Google for chemical match using the InChIKey | YNBQAYKYNYRCCA-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | YNBQAYKYNYRCCA |
Search PubMed clinical trials | venadaparib |
Search PubMed titles | venadaparib |
Search PubMed titles/abstracts | venadaparib |
UniChem Compound Search for chemical match using the InChIKey | YNBQAYKYNYRCCA-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | YNBQAYKYNYRCCA-UHFFFAOYSA-N |