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emtricitabine   Click here for help

GtoPdb Ligand ID: 11244

Abbreviated name: FTC
Synonyms: 524W91 | BW-524W91 | Coviracil® | Emtriva®
Approved drug PDB Ligand
emtricitabine is an approved drug (EMA & FDA (2003))
Compound class: Synthetic organic
Comment: Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) antiretroviral compound.
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emtricitabine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 115.67
Molecular weight 247.04
XLogP 0.28
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES Nc1nc(=O)n(cc1F)[C@@H]1CS[C@@H](O1)CO
Isomeric SMILES Nc1nc(=O)n(cc1F)[C@@H]1CS[C@@H](O1)CO
InChI InChI=1S/C8H10FN3O3S/c9-4-1-12(8(14)11-7(4)10)5-3-16-6(2-13)15-5/h1,5-6,13H,2-3H2,(H2,10,11,14)/t5-,6+/m0/s1
InChI Key XQSPYNMVSIKCOC-NTSWFWBYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EU EMA (2003)  |  US FDA (2003)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
International Nonproprietary Names Click here for help
INN number INN
7822 emtricitabine
Synonyms Click here for help
524W91 | BW-524W91 | Coviracil® | Emtriva®
Database Links Click here for help
CAS Registry No. 143491-57-0 (source: Scifinder)
ChEBI CHEBI:31536
ChEMBL Ligand CHEMBL885
DrugCentral Ligand 1003
GtoPdb PubChem SID 434122304
PubChem CID 60877
RCSB PDB Ligand ETV
Search Google for chemical match using the InChIKey XQSPYNMVSIKCOC-NTSWFWBYSA-N
Search Google for chemicals with the same backbone XQSPYNMVSIKCOC
Search PubMed clinical trials emtricitabine
Search PubMed titles emtricitabine
Search PubMed titles/abstracts emtricitabine
UniChem Compound Search for chemical match using the InChIKey XQSPYNMVSIKCOC-NTSWFWBYSA-N
UniChem Connectivity Search for chemical match using the InChIKey XQSPYNMVSIKCOC-NTSWFWBYSA-N
Wikipedia Emtricitabine

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Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

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MedChemExpress
Emtricitabine (links to external site)
Cat. No. HY-17427