opipramol   Click here for help

GtoPdb Ligand ID: 11247

Synonyms: Insidon®
Approved drug
opipramol is an approved drug
Compound class: Synthetic organic
Comment: Opipramol is an atypical tricyclic antidepressant (TCA) [3]. It acts primarily as a sigma (σ) receptor agonist. Weak antiviral activity of opipramol dihydrochloride against SARS-CoV-2 (in Vero E6 cells; EC50 5 μM) was reported by Touret et al. [4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 29.95
Molecular weight 363.23
XLogP 3.25
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCCN1CCN(CC1)CCCN1c2ccccc2C=Cc2c1cccc2
Isomeric SMILES OCCN1CCN(CC1)CCCN1c2ccccc2C=Cc2c1cccc2
InChI InChI=1S/C23H29N3O/c27-19-18-25-16-14-24(15-17-25)12-5-13-26-22-8-3-1-6-20(22)10-11-21-7-2-4-9-23(21)26/h1-4,6-11,27H,5,12-19H2
InChI Key YNZFUWZUGRBMHL-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
IUPAC Name Click here for help
2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol
International Nonproprietary Names Click here for help
INN number INN
1838 opipramol
Synonyms Click here for help
Insidon®
Database Links Click here for help
BindingDB Ligand 50170636
CAS Registry No. 315-72-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL370753
DrugBank Ligand DB12930
DrugCentral Ligand 1993
GtoPdb PubChem SID 434122307
PubChem CID 9417
Search Google for chemical match using the InChIKey YNZFUWZUGRBMHL-UHFFFAOYSA-N
Search Google for chemicals with the same backbone YNZFUWZUGRBMHL
Search PubMed clinical trials opipramol
Search PubMed titles opipramol
Search PubMed titles/abstracts opipramol
UniChem Compound Search for chemical match using the InChIKey YNZFUWZUGRBMHL-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey YNZFUWZUGRBMHL-UHFFFAOYSA-N