Synonyms: decanoyl-Arg-Val-Lys-Arg-CMK | Decanoyl-RVKR-CMK
Compound class:
Synthetic organic
Comment: Decanoyl-RVKR-CMK is a cell‐permeable and irreversible inhibitor of proprotein convertase (PC) enzymes [2]. The PC family of serine proteases includes furin. Furin-mediated cleavage of HIV-1 envelope glycoprotein 160 (gp160) is essential for fusion of the viral envelope with the host cell membrane [2].
SARS-CoV-2: Decanoyl-RVKR-CMK inhibits cleavage of SARS-CoV-2 spike protein by furin, at the furin cleavage site, and this translates to an antiviral effect in vitro [1]. |
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Classification ![]() |
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Compound class | Synthetic organic |
Synonyms ![]() |
decanoyl-Arg-Val-Lys-Arg-CMK | Decanoyl-RVKR-CMK |
Database Links ![]() |
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CAS Registry No. | 150113-99-8 (source: PubChem) |
GtoPdb PubChem SID | 434321693 |
PubChem CID | 9962075 |
Search Google for chemical match using the InChIKey | NHBJTTGFHCHQHS-VZTVMPNDSA-N |
Search Google for chemicals with the same backbone | NHBJTTGFHCHQHS |
UniChem Compound Search for chemical match using the InChIKey | NHBJTTGFHCHQHS-VZTVMPNDSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NHBJTTGFHCHQHS-VZTVMPNDSA-N |