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Synonyms: decanoyl-Arg-Val-Lys-Arg-CMK | Decanoyl-RVKR-CMK
Compound class: Synthetic organic
Comment: Decanoyl-RVKR-CMK is a cell‐permeable and irreversible inhibitor of proprotein convertase (PC) enzymes . The PC family of serine proteases includes furin. Furin-mediated cleavage of HIV-1 envelope glycoprotein 160 (gp160) is essential for fusion of the viral envelope with the host cell membrane .
SARS-CoV-2: Decanoyl-RVKR-CMK inhibits cleavage of SARS-CoV-2 spike protein by furin, at the furin cleavage site, and this translates to an antiviral effect in vitro .
|Compound class||Synthetic organic|
|decanoyl-Arg-Val-Lys-Arg-CMK | Decanoyl-RVKR-CMK|
|CAS Registry No.||150113-99-8 (source: PubChem)|
|GtoPdb PubChem SID||434321693|
|Search Google for chemical match using the InChIKey||NHBJTTGFHCHQHS-VZTVMPNDSA-N|
|Search Google for chemicals with the same backbone||NHBJTTGFHCHQHS|
|Search UniChem for chemical match using the InChIKey||NHBJTTGFHCHQHS-VZTVMPNDSA-N|
|Search UniChem for chemicals with the same backbone||NHBJTTGFHCHQHS|