ombitasvir   Click here for help

GtoPdb Ligand ID: 11272

Synonyms: ABT-267 | ABT267 | compound 38 [PMID: 24400777] | Technivie® (ombitasvir + paritaprevir + ritonavir) | Viekirax® (ombitasvir + paritaprevir + ritonavir; EU)
Approved drug
ombitasvir is an approved drug (FDA (2015), EMA (2020))
Compound class: Synthetic organic
Comment: Ombitasvir is an orally available, direct-acting inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex [1]. In common with many other NS5A inhibitors it is a dinucleotide derivative.

ombitasvir is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 15
Hydrogen bond donors 4
Rotatable bonds 22
Topological polar surface area 178.72
Molecular weight 893.51
XLogP 7.7
No. Lipinski's rules broken 3

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)[C@@H]1CC[C@H](N1c1ccc(cc1)C(C)(C)C)c1ccc(cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)OC)C(C)C
Isomeric SMILES COC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)[C@@H]1CC[C@H](N1c1ccc(cc1)C(C)(C)C)c1ccc(cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)OC)C(C)C
InChI InChI=1S/C50H67N7O8/c1-30(2)42(53-48(62)64-8)46(60)55-28-10-12-40(55)44(58)51-35-20-14-32(15-21-35)38-26-27-39(57(38)37-24-18-34(19-25-37)50(5,6)7)33-16-22-36(23-17-33)52-45(59)41-13-11-29-56(41)47(61)43(31(3)4)54-49(63)65-9/h14-25,30-31,38-43H,10-13,26-29H2,1-9H3,(H,51,58)(H,52,59)(H,53,62)(H,54,63)/t38-,39-,40-,41-,42-,43-/m0/s1
InChI Key PIDFDZJZLOTZTM-KHVQSSSXSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2015), EMA (2020))
Approved drug? Yes. FDA (2015)  |  EMA (2020)
Withdrawn drug? Yes
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
methyl N-[(2S)-1-[(2S)-2-[[4-[(2S,5S)-1-(4-tert-butylphenyl)-5-[4-[[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]phenyl]pyrrolidin-2-yl]phenyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
International Nonproprietary Names Click here for help
INN number INN
9740 ombitasvir
Synonyms Click here for help
ABT-267 | ABT267 | compound 38 [PMID: 24400777] | Technivie® (ombitasvir + paritaprevir + ritonavir) | Viekirax® (ombitasvir + paritaprevir + ritonavir; EU)
Database Links Click here for help
CAS Registry No. 1258226-87-7 (source: WHO INN record)
ChEMBL Ligand CHEMBL3127326
DrugBank Ligand DB09296
DrugCentral Ligand 4912
GtoPdb PubChem SID 434321707
PubChem CID 54767916
Search Google for chemical match using the InChIKey PIDFDZJZLOTZTM-KHVQSSSXSA-N
Search Google for chemicals with the same backbone PIDFDZJZLOTZTM
Search PubMed clinical trials ombitasvir
Search PubMed titles ombitasvir
Search PubMed titles/abstracts ombitasvir
UniChem Compound Search for chemical match using the InChIKey PIDFDZJZLOTZTM-KHVQSSSXSA-N
UniChem Connectivity Search for chemical match using the InChIKey PIDFDZJZLOTZTM-KHVQSSSXSA-N

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MedChemExpress
Ombitasvir (links to external site)
Cat. No. HY-13997