NYX-2925   Click here for help

GtoPdb Ligand ID: 11289

Synonyms: NYX2925
Compound class: Synthetic organic
Comment: NYX-2925 is a oral, brain-penetrating, NMDA receptor modulator that was developed by Aptinyx [2]. It acts as a co-agonist to glutamate and partially activates NMDARs. NYX-2925 is being investigated for potential to modulate neural pathways relevant for chronic pain.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 103.94
Molecular weight 297.17
XLogP -1.69
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CC(C(=O)N1CCC[C@@]21CN(C2=O)[C@H](C(=O)N)[C@H](O)C)C
Isomeric SMILES CC(C(=O)N1CCC[C@@]21CN(C2=O)[C@H](C(=O)N)[C@H](O)C)C
InChI InChI=1S/C14H23N3O4/c1-8(2)12(20)17-6-4-5-14(17)7-16(13(14)21)10(9(3)18)11(15)19/h8-10,18H,4-7H2,1-3H3,(H2,15,19)/t9-,10+,14-/m1/s1
InChI Key NFXPEHLDVKVVKA-ISTVAULSSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
(2S,3R)-3-hydroxy-2-[(4R)-5-(2-methylpropanoyl)-3-oxo-2,5-diazaspiro[3.4]octan-2-yl]butanamide
Synonyms Click here for help
NYX2925
Database Links Click here for help
GtoPdb PubChem SID 434321724
PubChem CID 122594417
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