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Synonyms: D-18506 | D18506 | Impavido® | Miltex® | n-hexadecylphosphorylcholine
miltefosine is an approved drug (FDA (2014))
Compound class: Synthetic organic
Comment: Miltefosine is an antiprotozoal (anthelmintic) drug that is primarily used to treat leishmaniasis. It has additional anticancer and immunomodulatory/anti-inflammatory activities . The antitumour activity of miltefosine is principally mediated through the inhibition of Akt phosphorylation , which exerts a modulatory effect on the phosphatidylinositol 3-kinase (PI3K)-Akt/PKB cellular survival pathway.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Yes (FDA (2014))
|WHO Essential Medicine
|WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|hexadecyl 2-(trimethylazaniumyl)ethyl phosphate
|International Nonproprietary Names
|D-18506 | D18506 | Impavido® | Miltex® | n-hexadecylphosphorylcholine
|CAS Registry No.
|58066-85-6 (source: PubChem)
|GtoPdb PubChem SID
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