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talarozole   Click here for help

GtoPdb Ligand ID: 11381

Synonyms: R-115866 | R115866 | Rambazole®
Compound class: Synthetic organic
Comment: Talarozole (R115866) is a cytochrome P450 CYP26 inhibitor. It was investigated for clinical efficacy as a treatment for cutaneous inflammation, including psoriasis.

talarozole is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.87
Molecular weight 377.17
XLogP 4.89
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCC(C(n1cncn1)c1ccc(cc1)Nc1nc2c(s1)cccc2)CC
Isomeric SMILES CCC(C(n1cncn1)c1ccc(cc1)Nc1nc2c(s1)cccc2)CC
InChI InChI=1S/C21H23N5S/c1-3-15(4-2)20(26-14-22-13-23-26)16-9-11-17(12-10-16)24-21-25-18-7-5-6-8-19(18)27-21/h5-15,20H,3-4H2,1-2H3,(H,24,25)
InChI Key SNFYYXUGUBUECJ-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
N-[4-[2-ethyl-1-(1,2,4-triazol-1-yl)butyl]phenyl]-1,3-benzothiazol-2-amine
International Nonproprietary Names Click here for help
INN number INN
8964 talarozole
Synonyms Click here for help
R-115866 | R115866 | Rambazole®
Database Links Click here for help
BindingDB Ligand 50253810
CAS Registry No. 201410-53-9 (source: PubChem)
ChEMBL Ligand CHEMBL459505
DrugBank Ligand DB13083
GtoPdb PubChem SID 440816750
PubChem CID 9799888
Search Google for chemical match using the InChIKey SNFYYXUGUBUECJ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SNFYYXUGUBUECJ
Search PubMed clinical trials talarozole
Search PubMed titles talarozole
Search PubMed titles/abstracts talarozole
UniChem Compound Search for chemical match using the InChIKey SNFYYXUGUBUECJ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey SNFYYXUGUBUECJ-UHFFFAOYSA-N

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MedChemExpress
Talarozole (links to external site)
Cat. No. HY-14531