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Synonyms: CD24-Fc  | CD24Fc
Compound class: Peptide or derivative
Comment: MK-7110 (originally OncoImmune's CD24Fc) is a synthetic protein that fuses the nonpolymorphic regions of CD24 (which is an agonist of Siglec-10) to the Fc region of human IgG1 . It.is being investigated as a modulator of the innate immune system, originally as an intervention to ameliorate graft-versus-host disease in leukemia patients receiving stem cell transplants, or autoimmune diseases. The peptide's sequence was extracted from OncoImmune's patent US20130231464A1 ; the first 30 amino acids are the CD24 region and the remainder belong to the IgG1 Fc domain.
SARS-CoV-2 and COVID-19: Preclinical evidence in primate viral infection models showed that MK-7110 offered potential as a non-antiviral biological modality that could be applied to reduce inflammation in SARS-CoV-2 infection.