GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.
|
Synonyms: CD24-Fc [2] | CD24Fc
Compound class:
Peptide
Comment: MK-7110 (originally OncoImmune's CD24Fc) is a synthetic protein that fuses the nonpolymorphic regions of CD24 (which is an agonist of Siglec-10) to the Fc region of human IgG1 [2]. It.is being investigated as a modulator of the innate immune system, originally as an intervention to ameliorate graft-versus-host disease in leukemia patients receiving stem cell transplants, or autoimmune diseases. The peptide's sequence was extracted from OncoImmune's patent US20130231464A1 [4]; the first 30 amino acids are the CD24 region and the remainder belong to the IgG1 Fc domain.
SARS-CoV-2 and COVID-19: Preclinical evidence in primate viral infection models showed that MK-7110 offered potential as a non-antiviral biological modality that could be applied to reduce inflammation in SARS-CoV-2 infection. |
For advanced searching click here to open chemical structure editor
Other Similar Sequences  |
|
| rilonacept |
Targetsnull |
| abatacept |
TargetsCD80; CD86 |
| belatacept |
TargetsCD80; CD86 |
| romiplostim |
TargetsThrombopoietin receptor |
| trebananib |
Targetsnull |
| resokine | |
| efgartigimod alfa |
TargetsFc fragment of IgG receptor and transporter |
| luspatercept |
Targetsnull |
| inbakicept | |
| sotatercept |
Targetsnull |
| efzofitimod | |
