Synonyms: VERU-111 | VERU111
Compound class:
Synthetic organic
Comment: Sabizabulin (VERU-111) is an orally bioavailable βIII/βIV-tubulin inhibitor that was developed for anti-tumour potential [1-2]. It interacts with the tubulin colchicine binding site. VERU-111 induces mitotic arrest and apoptosis in cancer cells in vitro, and inhibits xenograft tumour growth. It is suggested that like colchicine, VERU-111 may have anti-viral and anti-inflammatory actions in addition to its antiproliferative activity.
COVID-19: Sabizabulin has been repositioned as a potential therapeutic for COVID-19; in particular for patients who are hospitalised with moderate to severe COVID-19 and who are at high risk for developing acute respiratory distress syndrome (ARDS). |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
[2-(1H-indol-3-yl)-1H-imidazol-5-yl]-(3,4,5-trimethoxyphenyl)methanone |
International Nonproprietary Names | |
INN number | INN |
12055 | sabizabulin |
Synonyms |
VERU-111 | VERU111 |
Database Links | |
CAS Registry No. | 1332881-26-1 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL2163631 |
GtoPdb PubChem SID | 440816791 |
PubChem CID | 53379371 |
RCSB PDB Ligand | KUM |
Search Google for chemical match using the InChIKey | WQGVHOVEXMOLOK-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | WQGVHOVEXMOLOK |
Search PubMed clinical trials | sabizabulin |
Search PubMed titles | sabizabulin |
Search PubMed titles/abstracts | sabizabulin |
UniChem Compound Search for chemical match using the InChIKey | WQGVHOVEXMOLOK-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | WQGVHOVEXMOLOK-UHFFFAOYSA-N |