Synonyms: Cereblon modulator 1 | Compound 1 [WO2019006299A1] [1] | compound 16 [PMID: 33591756]
Compound class:
Synthetic organic
Comment: CC-90009 is a clinical stage cereblon E3 ligase modulating drug (CELMoD), that targets the G1 to S phase transition 1 (GSPT1, a.k.a. eRF3A) protein for degradation via the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex [2]. Binding of CC-90009 to cereblon alters its conformation, and promotes a change in substrate selectivity away from the transcription factors IKZF1/3 and towards to GSPT1. CC-90009-induced depletion of GSPT1 promotes apoptosis of acute myeloid leukemia (AML) cells via activation of the GCN1/GCN2/ATF4 pathway [3-4].
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide |
Synonyms ![]() |
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Cereblon modulator 1 | Compound 1 [WO2019006299A1] [1] | compound 16 [PMID: 33591756] |
Database Links ![]() |
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CAS Registry No. | 1860875-51-9 (source: PubChem) |
GtoPdb PubChem SID | 440816793 |
PubChem CID | 118647211 |
Search Google for chemical match using the InChIKey | PWBHUSLMHZLGRN-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | PWBHUSLMHZLGRN |
UniChem Compound Search for chemical match using the InChIKey | PWBHUSLMHZLGRN-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | PWBHUSLMHZLGRN-UHFFFAOYSA-N |