GS-441524   Click here for help

GtoPdb Ligand ID: 11445

Synonyms: EVO-984 | EVO984 | GS441524
PDB Ligand
Compound class: Synthetic organic
Comment: GS-441524 is the parent nucleoside that is metabolically liberated from remdesivir. Both compounds block RNA transcription by inhibiting the viral RNA-dependent RNA polymerase (RdRP). GS-441524 is the major metabolite and persists in the circulation with a longer half-life than remdesivir. GS-441524 potently inhibits SARS-CoV-2 replication in in vitro and in vivoinfection models [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 8
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 149.92
Molecular weight 291.1
XLogP -1.62
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC[C@H]1O[C@@]([C@@H]([C@@H]1O)O)(C#N)c1ccc2n1ncnc2N
Isomeric SMILES OC[C@H]1O[C@@]([C@@H]([C@@H]1O)O)(C#N)c1ccc2n1ncnc2N
InChI InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
InChI Key BRDWIEOJOWJCLU-LTGWCKQJSA-N
Classification Click here for help
Compound class Synthetic organic
Prodrug remdesivir
Synonyms Click here for help
EVO-984 | EVO984 | GS441524
Database Links Click here for help
ChEMBL Ligand CHEMBL2016757
GtoPdb PubChem SID 440816814
PubChem CID 44468216
RCSB PDB Ligand U08
Search Google for chemical match using the InChIKey BRDWIEOJOWJCLU-LTGWCKQJSA-N
Search Google for chemicals with the same backbone BRDWIEOJOWJCLU
UniChem Compound Search for chemical match using the InChIKey BRDWIEOJOWJCLU-LTGWCKQJSA-N
UniChem Connectivity Search for chemical match using the InChIKey BRDWIEOJOWJCLU-LTGWCKQJSA-N