|
Synonyms: AMG 181 | AMG-181 | MEDI-7183 | MEDI7183
Compound class:
Antibody
Comment: Abrilumab (AMG-181, MEDI-7183) is a fully human IgG2κ monoclonal antibody which selectively targets α4β7 integrin heterodimers [1] that was developed by MedImmune. It was designed for the treatment of inflammatory bowel diseases (ulcerative colitis [2], and Crohn's disease).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification  |
|
| Compound class | Antibody |
| International Nonproprietary Names |
|
| INN number | INN |
| 9921 | abrilumab |
| Synonyms |
| AMG 181 | AMG-181 | MEDI-7183 | MEDI7183 |
| Database Links |
|
| Specialist databases | |
| IMGT/mAb-DB | 495 |
| Other databases | |
| DrugBank Ligand | DB15076 |
| GtoPdb PubChem SID | 441604903 |
| Search PubMed clinical trials | abrilumab |
| Search PubMed titles | abrilumab |
| Search PubMed titles/abstracts | abrilumab |
