RB3007   Click here for help

GtoPdb Ligand ID: 11652

Synonyms: RB 3007 | RB-3007
Compound class: Synthetic organic
Comment: RB3007 is a systemically delivered, dual inhibitor of the enkephalin-degrading enzymes neutral endopeptidase/aminopeptidase N [1]. It can be used as an in vivo biological tool. Aminopeptidase N/neprilysin inhibition with RB3007 induces an elevation in the levels of the two endogenous enkephalins [Met]enkephalin and [Leu]enkephalin, Prodrugs with this mechanism of action are known collectively as Dual Enkephalinase Inhibitors, or DENKIs.
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 19
Topological polar surface area 159.9
Molecular weight 672.24
XLogP 6.18
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES CC(=O)SCCOP(=O)([C@H](c1ccccc1)N)C[C@H](C(=O)N[C@H](C(=O)OCc1ccccc1)C)Cc1ccc(cc1)c1ccccc1
Isomeric SMILES N[C@H](P(=O)(OCCSC(=O)C)C[C@H](C(=O)N[C@H](C(=O)OCc1ccccc1)C)Cc1ccc(cc1)c1ccccc1)c1ccccc1
InChI InChI=1S/C37H41N2O6PS/c1-27(37(42)44-25-30-12-6-3-7-13-30)39-36(41)34(24-29-18-20-32(21-19-29)31-14-8-4-9-15-31)26-46(43,45-22-23-47-28(2)40)35(38)33-16-10-5-11-17-33/h3-21,27,34-35H,22-26,38H2,1-2H3,(H,39,41)/t27-,34+,35+,46?/m0/s1
InChI Key PYJMLILRVYLUHW-UNCDKACKSA-N
Classification Click here for help
Compound class Synthetic organic
Synonyms Click here for help
RB 3007 | RB-3007
Database Links Click here for help
GtoPdb PubChem SID 442878678
PubChem CID 11072779
Search Google for chemical match using the InChIKey PYJMLILRVYLUHW-UNCDKACKSA-N
Search Google for chemicals with the same backbone PYJMLILRVYLUHW
UniChem Compound Search for chemical match using the InChIKey PYJMLILRVYLUHW-UNCDKACKSA-N
UniChem Connectivity Search for chemical match using the InChIKey PYJMLILRVYLUHW-UNCDKACKSA-N