Synonyms: MG277
Compound class:
Synthetic organic
Comment: MG-277 is a molecular glue type protein degrader [1]. It is a structurally modified analogue of MD-222 which is a MDM2 PROTAC degrader. The cereblon-binding moiety of MG-277 is required for its growth inhibitory effects on cancer cells. MG-277 achieves its potent anticancer activity by inducing degradation of the translation termination factor GSPT1 (a.k.a. eRF3a; GSPT1; P15170), and this is independent of MDM2.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms |
MG277 |
Database Links | |
BindingDB Ligand | 50505628 |
ChEMBL Ligand | CHEMBL4449512 |
GtoPdb PubChem SID | 458923759 |
PubChem CID | 139600332 |
Search Google for chemical match using the InChIKey | BANRYGZZIMCKNA-OYGJEQPESA-N |
Search Google for chemicals with the same backbone | BANRYGZZIMCKNA |
UniChem Compound Search for chemical match using the InChIKey | BANRYGZZIMCKNA-OYGJEQPESA-N |
UniChem Connectivity Search for chemical match using the InChIKey | BANRYGZZIMCKNA-OYGJEQPESA-N |