galegenimab   Click here for help

GtoPdb Ligand ID: 11759

Synonyms: 15H6v4.D221 | FHTR2163 | RG-6147 | RG6147 | RO-7171009 | RO7171009
Compound class: Antibody
Comment: Galegenimab is the INN that has been assigned to Genentech's anti-HTRA1 (HtrA serine peptidase 1) Fab antibody [6]. The antibody and its use are claimed in patent WO2017075212A1 [3]. HTRA1 is a serine protease whose substrates include transforming growth factor β [1,5], fibronectin, amyloid precursor protein [2] and Dickkop-related protein 3 (DKK3) [4]. Genetic polymorphisms in the HTRA1 gene are associated with an increased risk of developing neovascular age-related macular degeneration (and geographic atrophy) and with disease progression. Thus inhibition of HTRA1 proteolytic activity is being investigated for this ocular indication.
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Classification Click here for help
Compound class Antibody
Synonyms Click here for help
15H6v4.D221 | FHTR2163 | RG-6147 | RG6147 | RO-7171009 | RO7171009
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1169