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Synonyms: hPMAb22 [3] | PBP-1510 | PBP1510
Compound class:
Antibody
Comment: The INN record for ulenistamab identifies this as a hunamised monoclonal antibody directed against a protein called pancreatic adenocarcinoma up-regulated factor (PAUF). PAUF appears to be a product of the zymogen granule protein 16B gene ZG16B (UniProt accession Q96DA0), that is aberrantly expressed in some cancers [1,4], and which is involved in tumour development and metastasis [2]. The peptide sequences of the heavy and light chains of ulenistamab are claimed in patent WO2019022281A1 [3].
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| Bioactivity Comments |
| Ulenistamab (as hPMAb22) binds to recombinant PAUF with an affinity constant (Kd) of 0.19 nM [3]. |
