TRV026   Click here for help

GtoPdb Ligand ID: 11944

Synonyms: TRV 026 | TRV-026
Compound class: Peptide
Comment: TRV026 is an angiotensin II (AngII) analogue, in which the C-terminal Phe8 residue is deleted [2]. This truncation attenuates Gq-mediated signalling, and promotes β-arrestin-dependent receptor endocytosis.
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES NCCCC[C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N)Cc1[nH]cnc1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CNC)CCCN=C(N)N)Cc1ccc(cc1)O
Isomeric SMILES CC(C)[C@@H](C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC
InChI InChI=1S/C40H64N14O8/c1-23(2)33(53-36(59)27(49-32(56)21-45-3)9-6-16-47-40(43)44)38(61)51-29(18-24-11-13-26(55)14-12-24)37(60)50-28(8-4-5-15-41)35(58)52-30(19-25-20-46-22-48-25)39(62)54-17-7-10-31(54)34(42)57/h11-14,20,22-23,27-31,33,45,55H,4-10,15-19,21,41H2,1-3H3,(H2,42,57)(H,46,48)(H,49,56)(H,50,60)(H,51,61)(H,52,58)(H,53,59)(H4,43,44,47)/t27-,28-,29-,30-,31-,33-/m0/s1
InChI Key BMVQKFSALBOKAG-YYTVJKPMSA-N
Classification Click here for help
Compound class Peptide
Synonyms Click here for help
TRV 026 | TRV-026
Database Links Click here for help
Specialist databases
GPCRdb Ligand TRV026
Other databases
ChEMBL Ligand CHEMBL4544228
GtoPdb PubChem SID 461663499
PubChem CID 155552190
Search Google for chemical match using the InChIKey BMVQKFSALBOKAG-YYTVJKPMSA-N
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UniChem Compound Search for chemical match using the InChIKey BMVQKFSALBOKAG-YYTVJKPMSA-N
UniChem Connectivity Search for chemical match using the InChIKey BMVQKFSALBOKAG-YYTVJKPMSA-N