GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

latamoxef   Click here for help

GtoPdb Ligand ID: 12031

Synonyms: 6059-S | LY127935 | moxalactam | Moxam®
Approved drug
latamoxef is an approved drug (FDA (1981))
Compound class: Synthetic organic
Comment: Latamoxef is an oxacephem molecule developed by the Shionogi Research Laboratories (Osaka, Japan) [3]. It belongs to the β-lactam class of antibacterial compounds.
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 13
Hydrogen bond donors 4
Rotatable bonds 10
Topological polar surface area 231.6
Molecular weight 520.1
XLogP 0.3
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES CO[C@@]1(NC(=O)C(c2ccc(cc2)O)C(=O)O)C(=O)N2[C@@H]1OCC(=C2C(=O)O)CSc1nnnn1C
Isomeric SMILES Cn1c(nnn1)SCC1=C(N2[C@@H]([C@@](C2=O)(NC(=O)C(c2ccc(cc2)O)C(=O)O)OC)OC1)C(=O)O
InChI InChI=1S/C20H20N6O9S/c1-25-19(22-23-24-25)36-8-10-7-35-18-20(34-2,17(33)26(18)13(10)16(31)32)21-14(28)12(15(29)30)9-3-5-11(27)6-4-9/h3-6,12,18,27H,7-8H2,1-2H3,(H,21,28)(H,29,30)(H,31,32)/t12?,18-,20+/m1/s1
InChI Key JWCSIUVGFCSJCK-CAVRMKNVSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Brown RB, Klar J, Lemeshow S, Teres D, Pastides H, Sands M. (1986)
Enhanced bleeding with cefoxitin or moxalactam. Statistical analysis within a defined population of 1493 patients.
Arch Intern Med, 146 (11): 2159-64. [PMID:3778044]
2. Carmine AA, Brogden RN, Heel RC, Romankiewicz JA, Speight TM, Avery GS. (1983)
Moxalactam (latamoxef). A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.
Drugs, 26 (4): 279-333. [PMID:6354685]
3. Otsuka H, Nagata W, Yoshioka M, Narisada M, Yoshida T, Harada Y, Yamada H. (1981)
Discovery and development of Moxalactam (6059-S): the chemistry and biology of 1-oxacephems.
Med Res Rev, 1 (3): 217-48. [PMID:6213825]
4. Weitekamp MR, Aber RC. (1983)
Prolonged bleeding times and bleeding diathesis associated with moxalactam administration.
JAMA, 249 (1): 69-71. [PMID:6217353]