Synonyms: MLN 4924 | MLN-4924 | MLN4924 | TAK-924 | TAK924
Compound class:
Synthetic organic
Comment: Pevonedistat (MLN4924) is an inhibitor of the NEDD8 activating enzyme (NAE) [1], which is a heterodimer of NAE1 (NAE1; Q13564) and UBA3 subunits. Pevonedistat is structurally similar to the NAE reaction product adenosine 5′-monophosphate (AMP), and interacts with nucleotide-binding site of NAE. NAE is essential for the NEDD8 conjugation pathway which controls the activity of the cullin-RING ubiquitin E3 ligases. NAE inhibitors are proposed to disrupt cullin-RING ligase-mediated protein turnover and to promote apoptosis in human tumour cells.
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Classification | |
Compound class | Synthetic organic |
International Nonproprietary Names | |
INN number | INN |
9605 | pevonedistat |
Synonyms |
MLN 4924 | MLN-4924 | MLN4924 | TAK-924 | TAK924 |
Database Links | |
BindingDB Ligand | 50285607 |
CAS Registry No. | 905579-51-3 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL1231160 |
DrugBank Ligand | DB11759 |
GtoPdb PubChem SID | 472319239 |
PubChem CID | 16720766 |
RCSB PDB Ligand | B39, B39 |
Search Google for chemical match using the InChIKey | MPUQHZXIXSTTDU-QXGSTGNESA-N |
Search Google for chemicals with the same backbone | MPUQHZXIXSTTDU |
Search PubMed clinical trials | pevonedistat |
Search PubMed titles | pevonedistat |
Search PubMed titles/abstracts | pevonedistat |
UniChem Compound Search for chemical match using the InChIKey | MPUQHZXIXSTTDU-QXGSTGNESA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MPUQHZXIXSTTDU-QXGSTGNESA-N |