Synonyms: HMS-5552 | HMS5552 | RO-5305552 | RO5305552 | Sinogliatin
dorzagliatin is an approved drug (China (2022))
Compound class:
Synthetic organic
Comment: Dorzagliatin (HMS5552) is an allosteric glucokinase (GCK) activator [3,5], that targets both pancreatic and hepatic GCK, and is a 'full' activator that increases GCK's maximum velocity (Vmax) [7]. GCK activators are being developed as novel drugs for the treatment of type 2 diabetes mellitus (T2DM) [1-2,4].
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (China (2022)) |
International Nonproprietary Names | |
INN number | INN |
10511 | dorzagliatin |
Synonyms |
HMS-5552 | HMS5552 | RO-5305552 | RO5305552 | Sinogliatin |
Database Links | |
ChEMBL Ligand | CHEMBL4297508 |
DrugBank Ligand | DB15123 |
GtoPdb PubChem SID | 472319246 |
PubChem CID | 57920094 |
Search Google for chemical match using the InChIKey | HMUMWSORCUWQJO-QAPCUYQASA-N |
Search Google for chemicals with the same backbone | HMUMWSORCUWQJO |
Search PubMed clinical trials | dorzagliatin |
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Search PubMed titles/abstracts | dorzagliatin |
UniChem Compound Search for chemical match using the InChIKey | HMUMWSORCUWQJO-QAPCUYQASA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HMUMWSORCUWQJO-QAPCUYQASA-N |