Synonyms: compound 11 [PMID: 23459613] | compound 11 [WO2014113467A1] | HJC-0152 | HJC-1-52 [3]
Compound class:
Synthetic organic
Comment: HJC0152 was originally identified as an orally bioavailable compound with anti-cancer properties [1], and weak anti-viral activity [2]. Its chemical structure is based upon that of the signal transducer and activator of transcription 3 (STAT3)-inhibiting compound niclosamide. STAT3 is an oncology drug target, since excessive activation of STAT3 occurs in cancers, and is a perdictor of poor prognosis. Blocking STAT3 signalling in many cancer cell types induces growth arrest and promotes apoptosis. To mour knowledge there is no quantitative data that supports the direct interaction of HJC0152 with STAT3.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
2-(2-aminoethoxy)-5-chloro-N-(2-chloro-4-nitrophenyl)benzamide |
Synonyms ![]() |
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compound 11 [PMID: 23459613] | compound 11 [WO2014113467A1] | HJC-0152 | HJC-1-52 [3] |
Database Links ![]() |
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CAS Registry No. | 1420290-88-5 (source: PubChem) |
ChEMBL Ligand | CHEMBL2326743 |
GtoPdb PubChem SID | 472319262 |
PubChem CID | 71527596 |
Search Google for chemical match using the InChIKey | DIMJVBOEXNWPOG-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | DIMJVBOEXNWPOG |
UniChem Compound Search for chemical match using the InChIKey | DIMJVBOEXNWPOG-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DIMJVBOEXNWPOG-UHFFFAOYSA-N |