Synonyms: BRD4-PROTAC 12a | WWL-0245
Compound class:
Synthetic organic
Comment: WWL0245 is a bifunctional cereblon-based PROTAC molecule that promotes ubiquitin-proteasomal degradation of BRD4 protein [1]. The BET domain-binding region is based on the dual BET/PLK1 inhibitor WNY0824. Cereblon binding is mediated via a modified thalidomide moiety. WWL0245 exhibits selective cytotoxicity in BET inhibitor sensitive cancer cell lines such as androgen receptor (AR)-positive prostate cancer cell lines, and it promotes a more potent anti-proliferative effect than the parent BET inhibitor.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
BRD4-PROTAC 12a | WWL-0245 |
Database Links ![]() |
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GtoPdb PubChem SID | 472319264 |
PubChem CID | 165368932 |
Search Google for chemical match using the InChIKey | AORZPRLVKUMTOJ-XGDNGBMYSA-N |
Search Google for chemicals with the same backbone | AORZPRLVKUMTOJ |
UniChem Compound Search for chemical match using the InChIKey | AORZPRLVKUMTOJ-XGDNGBMYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | AORZPRLVKUMTOJ-XGDNGBMYSA-N |