ponazuril   Click here for help

GtoPdb Ligand ID: 12223

Synonyms: ACD-855 | ACD855 | Marquis® (vet use only) | toltrazuril | toltrazuril sulfone
Compound class: Synthetic organic
Comment: Ponazuril is a safe and well tolerated anti-protozoal drug used in horses [2]. Repurposing efforts have identified it as a tropomyosin related kinase (Trk) receptor positive allosteric modulator (PAM), on the hypothesis that increasing NGF/BDNF signalling is predicted to improve neuronal cell functions and survival to boost cognitive capacity in neurological/neurodegenerative diseases. This work by AlzeCure Pharma led to ponazuril's re-naming with their in-house research code ACD855 [1]. ACD855 enhances signalling of the neurotrophins NGF and BDNF via TrkA and TrkB (repectively). It is structurally related to their TrkA-selective lead compound ACD856 that is in clinical development as a novel Alzheimer's disease therapeutic [5].

ACD856's chemical structure has not been disclosed (Oct 2022), but a number of derivatives with the same 1,3,5-triazine scaffold have been claimed as Trk PAMs in AlzeCure patents WO2020002950A1 [3] and WO2018115891A1 [4].

ponazuril is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 128.09
Molecular weight 457.38
XLogP 4
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES Cc1cc(ccc1Oc1ccc(cc1)S(=O)(=O)C(F)(F)F)n1c(=O)[nH]c(=O)n(c1=O)C
Isomeric SMILES Cc1c(ccc(c1)n1c(=O)[nH]c(=O)n(c1=O)C)Oc1ccc(cc1)S(=O)(=O)C(F)(F)F
InChI InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
InChI Key VBUNOIXRZNJNAD-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
1-methyl-3-[3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl]-1,3,5-triazinane-2,4,6-trione
International Nonproprietary Names Click here for help
INN number INN
7770 ponazuril
Synonyms Click here for help
ACD-855 | ACD855 | Marquis® (vet use only) | toltrazuril | toltrazuril sulfone
Database Links Click here for help
CAS Registry No. 69004-04-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL2104856
DrugBank Ligand DB11452
GtoPdb PubChem SID 472319343
PubChem CID 3050408
Search Google for chemical match using the InChIKey VBUNOIXRZNJNAD-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VBUNOIXRZNJNAD
Search PubMed clinical trials ponazuril
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Search PubMed titles/abstracts ponazuril
UniChem Compound Search for chemical match using the InChIKey VBUNOIXRZNJNAD-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey VBUNOIXRZNJNAD-UHFFFAOYSA-N

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MedChemExpress
Toltrazuril (sulfone) (links to external site)
Cat. No. HY-17008