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Synonyms: DF 2755A | DF-2755A
Compound class: Synthetic organic
Comment: DF2755A inhibits CXCL8 (IL-8) signalling via its endogenous chemokine receptors CXCR1 and CXCR2 . It does not alter the binding affinity of CXCL8 for either receptor, indicating that it is behaving as a negative allosteric modulator (NAM). Activation of the IL-8 pathway has been linked to the development of chemotherapy-induced neuropathic pain. It is predicted that inhibition of this mechanism might offer clinical utility for cancer patients who experience chemotherapy-induced peripheral neuropathy .
We show the carboxylic acid parent form for this compound, but DF2755A is used as the sodium salt.
|Compound class||Synthetic organic|
|DF 2755A | DF-2755A|
|GtoPdb PubChem SID||473153818|
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