Synonyms: DF 2755A | DF-2755A
Compound class:
Synthetic organic
Comment: DF2755A inhibits CXCL8 (IL-8) signalling via its endogenous chemokine receptors CXCR1 and CXCR2 [2]. It does not alter the binding affinity of CXCL8 for either receptor, indicating that it is behaving as a negative allosteric modulator (NAM). Activation of the IL-8 pathway has been linked to the development of chemotherapy-induced neuropathic pain. It is predicted that inhibition of this mechanism might offer clinical utility for cancer patients who experience chemotherapy-induced peripheral neuropathy [1].
We show the carboxylic acid parent form for this compound, but DF2755A is used as the sodium salt. |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
(2S)-2-[4-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino]phenyl]propanoic acid |
Synonyms ![]() |
DF 2755A | DF-2755A |
Database Links ![]() |
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ChEMBL Ligand | CHEMBL4520228 |
GtoPdb PubChem SID | 473153818 |
PubChem CID | 45110932 |
Search Google for chemical match using the InChIKey | OUGCUPYREMACGK-ZETCQYMHSA-N |
Search Google for chemicals with the same backbone | OUGCUPYREMACGK |
UniChem Compound Search for chemical match using the InChIKey | OUGCUPYREMACGK-ZETCQYMHSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | OUGCUPYREMACGK-ZETCQYMHSA-N |