mezlocillin   Click here for help

GtoPdb Ligand ID: 12272

Synonyms: BAYPEN® | Mezlin® | Multocillin®
Approved drug
mezlocillin is an approved drug (FDA (1981))
Compound class: Synthetic organic
Comment: Mezlocillin is a broad-spectrum penicillin antimicrobial compound that is active against both Gram-negative and some Gram-positive bacteria.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 13
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 207.18
Molecular weight 539.11
XLogP -0.04
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES O=C([C@@H](c1ccccc1)NC(=O)N1CCN(C1=O)S(=O)(=O)C)N[C@@H]1C(=O)N2[C@@H]1SC([C@@H]2C(=O)O)(C)C
Isomeric SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](c1ccccc1)NC(=O)N1CCN(C1=O)S(=O)(=O)C)C(=O)O)C
InChI InChI=1S/C21H25N5O8S2/c1-21(2)14(18(29)30)26-16(28)13(17(26)35-21)22-15(27)12(11-7-5-4-6-8-11)23-19(31)24-9-10-25(20(24)32)36(3,33)34/h4-8,12-14,17H,9-10H2,1-3H3,(H,22,27)(H,23,31)(H,29,30)/t12-,13-,14+,17-/m1/s1
InChI Key YPBATNHYBCGSSN-VWPFQQQWSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1981))
Approved drug? Yes. FDA (1981)
Withdrawn drug? Yes
IUPAC Name Click here for help
(2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[(3-methylsulfonyl-2-oxoimidazolidine-1-carbonyl)amino]-2-phenylacetyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
3898 mezlocillin
Synonyms Click here for help
BAYPEN® | Mezlin® | Multocillin®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Mezlocillin
Other databases
CAS Registry No. 51481-65-3 (source: Scifinder)
ChEBI CHEBI:6919
ChEMBL Ligand CHEMBL1731
DrugBank Ligand DB00948
DrugCentral Ligand 1795
GtoPdb PubChem SID 473153860
PubChem CID 656511
Search Google for chemical match using the InChIKey YPBATNHYBCGSSN-VWPFQQQWSA-N
Search Google for chemicals with the same backbone YPBATNHYBCGSSN
Search PubMed clinical trials mezlocillin
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Search PubMed titles/abstracts mezlocillin
UniChem Compound Search for chemical match using the InChIKey YPBATNHYBCGSSN-VWPFQQQWSA-N
UniChem Connectivity Search for chemical match using the InChIKey YPBATNHYBCGSSN-VWPFQQQWSA-N