Synonyms: Ac-Ala-Val-Ome
Compound class:
Peptide
Comment: ZZL-7 is a novel di-peptide with rapid-onset anti-depressant activity in in vivo models [1]. It binds to the PDZ domain of neuronal NOS (nNOS) and blocks its interaction with the serotonin (5-HT) transporter (SERT; SLC6A4) in the dorsal raphe nucleus (DRN). This mechanism increases SERT translocation the cell surface, in turn increasing 5-HT transport out of the cell and into the intracellular space, with a resulting increase in firing of serotonergic neurons. ZZL-7 has been shown to readily cross the blood-brain barrier in mice following intravenous injection.
|
|
Classification ![]() |
|
Compound class | Peptide |
IUPAC Name ![]() |
methyl (2S)-2-[(2S)-2-acetamidopropanamido]-3-methylbutanoate |
Synonyms ![]() |
Ac-Ala-Val-Ome |
Database Links ![]() |
|
GtoPdb PubChem SID | 479821107 |
PubChem CID | 166176924 |
Search Google for chemical match using the InChIKey | RHDUVXUSBMPQOK-CBAPKCEASA-N |
Search Google for chemicals with the same backbone | RHDUVXUSBMPQOK |
UniChem Compound Search for chemical match using the InChIKey | RHDUVXUSBMPQOK-CBAPKCEASA-N |
UniChem Connectivity Search for chemical match using the InChIKey | RHDUVXUSBMPQOK-CBAPKCEASA-N |