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Synonyms: AK-105 | AK105
penpulimab is an approved drug (China (2021))
Compound class:
Antibody
Comment: Penpulimab (AK-105) is a chimeric IgG1κ programmed cell death 1 (PD-1) monoclonal antibody [2]. Its engineered Fc structure means that it does not interact with Fcγ receptors and therefore it does not induce immune cell (macrophage) effector functions (antibody-dependent cell-mediated cytotoxicity/ADCC, antibody-dependent cellular phagocytosis/ADCP, antibody-dependent cytokine release/ADCR). Penpulimab binds to an epitope in human PD-1's N-glycosylation site (at residue N58).
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification  |
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| Compound class | Antibody |
| Ligand families/groups | Immune checkpoint modulators |
| Approved drug? | Yes (China (2021)) |
| International Nonproprietary Names |
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| INN number | INN |
| 11497 | penpulimab |
| Synonyms |
| AK-105 | AK105 |
| Database Links |
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| Specialist databases | |
| IMGT/mAb-DB | 1093 |
| Other databases | |
| GtoPdb PubChem SID | 479821138 |
| Search PubMed clinical trials | penpulimab |
| Search PubMed titles | penpulimab |
| Search PubMed titles/abstracts | penpulimab |
