sabatolimab   Click here for help

GtoPdb Ligand ID: 12361

Synonyms: MBG-453 | MBG453
Compound class: Antibody
Comment: Sabatolimab (MBG-453) is an anti-TIM3 (HAVCR2) monoclonal antibody [1-2], that was developed as a leukemia immunotherapy. It binds to TIM3 on myeloid cells, blocking the interaction between TIM3 and its endogenous ligands PtdSer/galectin 9. This action blocks TIM3's function as an immune co-inhibitory receptor, and promotes an immune response against neoplastic myeloid cells.
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Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
11256 sabatolimab
Synonyms Click here for help
MBG-453 | MBG453
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1030
Other databases
GtoPdb PubChem SID 479821152
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