Synonyms: OBI3424 | TH-3424 | TH3424
Compound class:
Synthetic organic
Comment: OBI-3424 is a prodrug that is converted (activated) by aldo-keto reductase family 1 member C3 (AKR1C3) into an intermediary metabolite that spontaneously hydrolyses to generate a thiotepa-related DNA alkylating (cross-linking) agent [1]. It was designed as a chemotherapeutic agent, and has demonstrated efficacy in preclinical models of T-cell acute lymphoblastic leukemia (T-ALL).
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
3-[5-[(1R)-1-[bis(aziridin-1-yl)phosphoryloxy]ethyl]-2-nitrophenoxy]-N,N-dimethylbenzamide |
Synonyms |
OBI3424 | TH-3424 | TH3424 |
Database Links | |
CAS Registry No. | 2097713-68-1 (source: PubChem) |
ChEMBL Ligand | CHEMBL4297474 |
GtoPdb PubChem SID | 483123318 |
PubChem CID | 126961329 |
RCSB PDB Ligand | 6LG |
Search Google for chemical match using the InChIKey | NWGZZGNICQFUHV-OAHLLOKOSA-N |
Search Google for chemicals with the same backbone | NWGZZGNICQFUHV |
UniChem Compound Search for chemical match using the InChIKey | NWGZZGNICQFUHV-OAHLLOKOSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NWGZZGNICQFUHV-OAHLLOKOSA-N |