Synonyms: GSK3036656 | GSK656
Compound class:
Synthetic organic
Comment: Ganfeborole (GSK3036656) is a first-in-class boron-containing antitubercular agent. It is the lead from a series of 3-aminomethylbenzoxaboroles that are potent inhibitors of Mycobacterium tuberculosis leucyl-tRNA synthetase (LeuRS) [2]. We show the (S) enantiomer, which is the most active form.
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-[[(3S)-3-(aminomethyl)-4-chloro-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]ethanol |
International Nonproprietary Names | |
INN number | INN |
12456 | ganfeborole |
Synonyms |
GSK3036656 | GSK656 |
Database Links | |
Specialist databases | |
Antibiotic DB | GSK656, GSK3036656, Ganfeborole |
Other databases | |
CAS Registry No. | 2131798-12-2 (source: Scifinder) |
ChEMBL Ligand | CHEMBL4116378 |
GtoPdb PubChem SID | 483123344 |
PubChem CID | 133080621 |
Search Google for chemical match using the InChIKey | DJUOWOXTPXUHDQ-MRVPVSSYSA-N |
Search Google for chemicals with the same backbone | DJUOWOXTPXUHDQ |
Search PubMed clinical trials | ganfeborole |
Search PubMed titles | ganfeborole |
Search PubMed titles/abstracts | ganfeborole |
UniChem Compound Search for chemical match using the InChIKey | DJUOWOXTPXUHDQ-MRVPVSSYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DJUOWOXTPXUHDQ-MRVPVSSYSA-N |