avacincaptad pegol   Click here for help

GtoPdb Ligand ID: 12857

Synonyms: ARC-1905 | ARC1905 | Izervay® | Zimura
Approved drug Immunopharmacology Ligand
avacincaptad pegol is an approved drug (FDA (2023))
Compound class: Nucleic acid
Comment: Avacincaptad pegol (ARC-1905) is a pegylated RNA aptamer that selectively binds to complement C5 and prevents its cleavage into C5a and C5b. This action inhibits activation of inflammasomes and the formation of membrane attack complexes (MAC).

In the sequence presented 'dfl' represents 2'-deoxy-2'-fluoro-modified bases and 'm' represents 2'-O-methyl modifications. The PEG is added at the 3' 'R'.
Classification Click here for help
Compound class Nucleic acid
Compound subclass Aptamer
Target complement C5 (C5)
Approved drug? Yes (FDA (2023))
International Nonproprietary Names Click here for help
INN number INN
10099 avacincaptad pegol
Synonyms Click here for help
ARC-1905 | ARC1905 | Izervay® | Zimura
Database Links Click here for help
CAS Registry No. 1613641-69-2 (source: WHO INN record)
ChEMBL Ligand CHEMBL4297889
DrugBank Ligand DB15165
GtoPdb PubChem SID 483123405
Search PubMed clinical trials avacincaptad pegol
Search PubMed titles avacincaptad pegol
Search PubMed titles/abstracts avacincaptad pegol