Synonyms: Compound A [WO2022174269A1] | KT474
Compound class:
Synthetic organic
Comment: KT-474 is a PROTAC degrader of interleukin 1 receptor associated kinase 4 (IRAK4). It is in Kymera Therapeutics' pipeline and is initially being developed for potential to treat the autoimmune conditions atopic dermatitis and hidradenitis suppurativa [2]. A thalidomide analogue moiety is employed to direct the bound IRAK4 to the ubiquitin-proteasome pathway via the thalidomide-cereblon interaction.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
Compound A [WO2022174269A1] | KT474 |
Database Links ![]() |
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CAS Registry No. | 2432994-31-3 (source: PubChem) |
GtoPdb PubChem SID | 485206013 |
PubChem CID | 146599824 |
Search Google for chemical match using the InChIKey | NQGKNAVUMAHSQN-PKIOHZLWSA-N |
Search Google for chemicals with the same backbone | NQGKNAVUMAHSQN |
UniChem Compound Search for chemical match using the InChIKey | NQGKNAVUMAHSQN-PKIOHZLWSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NQGKNAVUMAHSQN-PKIOHZLWSA-N |