Compound class:
Synthetic organic
Comment: TNG-462 (Tango Therapuetics) is a MTA-cooperative protein arginine methyltransferases 5 (PRMT5) inhibitor, that is proposed to treat methylthioadenosine phosphorylase (MTAP) deleted solid tumours. MTAP deficient cancer cells are unable to obtain adenine and methionine from the salvage pathway [1]. Adding inhibition of PRMT5 further decreases the viability of MTAP deficient cancer cells [2]. The chemical structure shown here was revealed during the First Time Disclosures session at the ACS meeting in September 2023, and we picked it up from Drug Hunter.
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
N-(6-amino-5-ethylpyridin-3-yl)-2-[(2R,5S)-5-methyl-2-[2-(1-methylpiperidin-4-yl)-1,3-benzothiazol-5-yl]piperidin-1-yl]-2-oxoacetamide |
Database Links | |
GtoPdb PubChem SID | 485206023 |
PubChem CID | 164752829 |
Search Google for chemical match using the InChIKey | DHAGMIPSRSPWSH-GAJHUEQPSA-N |
Search Google for chemicals with the same backbone | DHAGMIPSRSPWSH |
UniChem Compound Search for chemical match using the InChIKey | DHAGMIPSRSPWSH-GAJHUEQPSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DHAGMIPSRSPWSH-GAJHUEQPSA-N |