Synonyms: BWA522 | compound 28 [PMID: 37556600]
Compound class:
Synthetic organic
Comment: BWA-522 is an orally active cereblon-targeting PROTAC degrader of the androgen receptor (AR) [2]. It was designed for potential to treat advanced prostate cancer. BWA-522 binds to the N-terminal domain (NTD) of the AR using a warhead derived from the antagonist EPI-002 (ralaniten) [1]. Exploiting the NTD is proposed as a strategy to target both wild type ARs and mutated ARs that have no ligand-binding domain (LBD) and that are therefore unsusceptible to androgen-competitive antagonist drugs.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
5-(4-((4-((4-(2-(4-((S)-3-Chloro-2-hydroxypropoxy)phenyl)propan-2-yl)phenoxy)methyl)-piperidin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
Synonyms ![]() |
BWA522 | compound 28 [PMID: 37556600] |
Database Links ![]() |
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GtoPdb PubChem SID | 485206033 |
PubChem CID | 168679672 |
Search Google for chemical match using the InChIKey | MYCPBYLZNZTLBC-OVFDOZPJSA-N |
Search Google for chemicals with the same backbone | MYCPBYLZNZTLBC |
UniChem Compound Search for chemical match using the InChIKey | MYCPBYLZNZTLBC-OVFDOZPJSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MYCPBYLZNZTLBC-OVFDOZPJSA-N |