Synonyms: MD224
Compound class:
Synthetic organic
Comment: MD-224 is a PROTAC class degrader molecule of the MDM2 proto-oncogene (an E3 ubiquitin-protein ligase that acts as a negative regulator of the p53 tumour suppressor). PROTACs that recruit MDM2 simultaneously antagonise interaction with p53, promote MDM2 degradation and increase intracellular p53 [1-2]. MD-224 was designed to demonstrate the anti-tumour effect of this strategy.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
MD224 |
Database Links ![]() |
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CAS Registry No. | 2136247-12-4 (source: PubChem) |
ChEMBL Ligand | CHEMBL5187116 |
GtoPdb PubChem SID | 485206035 |
PubChem CID | 131986956 |
Search Google for chemical match using the InChIKey | ZLGNYFOIDAVMHY-MPKOGUQCSA-N |
Search Google for chemicals with the same backbone | ZLGNYFOIDAVMHY |
UniChem Compound Search for chemical match using the InChIKey | ZLGNYFOIDAVMHY-MPKOGUQCSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | ZLGNYFOIDAVMHY-MPKOGUQCSA-N |