Synonyms: compound 14 [PMID: 31747516] | SD36
Compound class:
Synthetic organic
Comment: SD-36 is a STAT3 PROTAC degrader [1-2]. It simultaneously binds to the SH1 domain of STAT3 and recruits the cereblon E3 ubiquitin ligase, to promote proteasomal degradation of STAT3. STAT3 degradation is a novel anti-cancer strategy, as an alternative to pharmacological inhibtion.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Suo Y, Du D, Chen C, Zhu H, Wang X, Song N, Lu D, Yang Y, Li J, Wang J et al.. (2024)
Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3. J Med Chem, 67 (6): 4804-4818. [PMID:38466231] |
2. Zhou H, Bai L, Xu R, Zhao Y, Chen J, McEachern D, Chinnaswamy K, Wen B, Dai L, Kumar P et al.. (2019)
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. J Med Chem, 62 (24): 11280-11300. [PMID:31747516] |