Synonyms: DNL-343
Compound class:
Synthetic organic
Comment: DNL343 is an investigational small molecule eIF2B activator [1]. It blocks activation of the integrated stress response (ISR), a biological process that plays a role in driving neurodegeneration in diseases such as ALS/MND and vanishing white matter disease (VWMD). DNL343 was designed to address ISR-mediated neurodegeneration.
The HGNC lists 4 human genes for eIF2B subunits (EIF2B1-EIF2B4). |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-(4-chlorophenoxy)-N-[3-[5-[3-(trifluoromethoxy)cyclobutyl]-1,3,4-oxadiazol-2-yl]-1-bicyclo[1.1.1]pentanyl]acetamide |
Synonyms |
DNL-343 |
Database Links | |
GtoPdb PubChem SID | 485206061 |
PubChem CID | 137491382 |
Search Google for chemical match using the InChIKey | IKPNRMYDOSNVAU-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | IKPNRMYDOSNVAU |
UniChem Compound Search for chemical match using the InChIKey | IKPNRMYDOSNVAU-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | IKPNRMYDOSNVAU-UHFFFAOYSA-N |