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sotatercept   Click here for help

GtoPdb Ligand ID: 12962

Synonyms: ACE-011 | ACE011 | ActRIIA-IgG1 | MK-7962 | MK7962 | sotatercept-csrk | Winrevair®
Approved drug
sotatercept is an approved drug (EMA & FDA (2024))
Compound class: Antibody
Comment: Sotatercept (MK-7962) is a soluble activin receptor 2A (ACVR2A; ActR2) ligand trap type inhibitor. Structurally it is a fusion protein of the extracellular domain of the ActR2 and a human IgG Fc domain. In pulmonary blood vessels sotatercept sequesters ActR2 endogenous ligands (e.g. activins A and B, and growth differentiation factors 8 and 11, BMP6 and BMP7), and prevents their interaction with ActR2s to restore normal cell proliferation [3,7].
Classification Click here for help
Compound class Antibody
Approved drug? Yes. US FDA (2024)
International Nonproprietary Names Click here for help
INN number INN
9188 sotatercept
Synonyms Click here for help
ACE-011 | ACE011 | ActRIIA-IgG1 | MK-7962 | MK7962 | sotatercept-csrk | Winrevair®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 331
Other databases
GtoPdb PubChem SID 485206083
Search PubMed clinical trials sotatercept
Search PubMed titles sotatercept
Search PubMed titles/abstracts sotatercept