Synonyms: BTZ-10526043 | MMV676603
Compound class:
Synthetic organic
Comment: BTZ-043 is the lead from a novel class of benzothiazinone compounds with antimycobacterial activity [1], that is is under clinical evaluated as a treatment for tuberculosis (TB). It is an inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme [1-3].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one |
Synonyms |
BTZ-10526043 | MMV676603 |
Database Links | |
Specialist databases | |
Antibiotic DB | BTZ-043, benzothiazinone |
Other databases | |
CAS Registry No. | 1161233-85-7 (source: Scifinder) |
ChEMBL Ligand | CHEMBL1822872 |
DrugBank Ligand | DB17737 |
GtoPdb PubChem SID | 485206155 |
PubChem CID | 42609849 |
Search Google for chemical match using the InChIKey | GTUIRORNXIOHQR-VIFPVBQESA-N |
Search Google for chemicals with the same backbone | GTUIRORNXIOHQR |
UniChem Compound Search for chemical match using the InChIKey | GTUIRORNXIOHQR-VIFPVBQESA-N |
UniChem Connectivity Search for chemical match using the InChIKey | GTUIRORNXIOHQR-VIFPVBQESA-N |