balofloxacin   Click here for help

GtoPdb Ligand ID: 13105

Synonyms: Q-35 | Q-Roxin®
Approved drug
balofloxacin is an approved drug (Korean FDA (2001))
Compound class: Synthetic organic
Comment: Balofloxacin is a fluoroquinolone antibacterial compound, with broad-spectrum activity against both Gram-positive and Gram-negative bacteria [2-3].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 82.11
Molecular weight 389.42
XLogP 2.8
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CNC1CCCN(C1)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)OC
Isomeric SMILES CNC1CCCN(C1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI InChI=1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)
InChI Key MGQLHRYJBWGORO-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (Korean FDA (2001))
IUPAC Name Click here for help
1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylaminopiperidin-1-yl)-4-oxoquinoline-3-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
7236 balofloxacin
Synonyms Click here for help
Q-35 | Q-Roxin®
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Balofloxacin, Q-35
Other databases
CAS Registry No. 127294-70-6 (source: Scifinder)
ChEMBL Ligand CHEMBL1210954
DrugCentral Ligand 283
GtoPdb PubChem SID 491299887
PubChem CID 65958
Search Google for chemical match using the InChIKey MGQLHRYJBWGORO-UHFFFAOYSA-N
Search Google for chemicals with the same backbone MGQLHRYJBWGORO
Search PubMed clinical trials balofloxacin
Search PubMed titles balofloxacin
Search PubMed titles/abstracts balofloxacin
UniChem Compound Search for chemical match using the InChIKey MGQLHRYJBWGORO-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey MGQLHRYJBWGORO-UHFFFAOYSA-N