Synonyms: AG-946 | AG946 | compound 27 [PMID: 38109501]
Compound class:
Synthetic organic
Comment: Tebapivat (AG-946) is a small molecule activator of pyruvate kinase (PK) [1]. It acts allosterically, at wild type PK and at physiologically relevent PK isoforms (e.g. PKR that's expressed in red blood cells). It is intended to increase PK function in red blood cells with defective glycolysis, as observed in diseases such as myelodysplastic syndromes and sickle cell anaemia.
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Classification | |
Compound class | Synthetic organic |
International Nonproprietary Names | |
INN number | INN |
12719 | tebapivat |
Synonyms |
AG-946 | AG946 | compound 27 [PMID: 38109501] |
Database Links | |
CAS Registry No. | 2283422-04-6 (source: WHO INN record) |
GtoPdb PubChem SID | 491299888 |
PubChem CID | 137501615 |
RCSB PDB Ligand | HVI |
Search Google for chemical match using the InChIKey | DIUOELXIXSCFCR-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | DIUOELXIXSCFCR |
Search PubMed clinical trials | tebapivat |
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UniChem Compound Search for chemical match using the InChIKey | DIUOELXIXSCFCR-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DIUOELXIXSCFCR-UHFFFAOYSA-N |