Synonyms: compound 19 [PMID: 38316017]
Compound class:
Synthetic organic
Comment: QC-182 is a PROTAC degrader of the structurally related bromodomain-containing histone acetyltransferases E1A binding protein (p300) and CREB binding protein (CBP) [1]. p300 and CBP are therapeutic targets for the development of anti-tumour drugs. QC-182 uses thalidomide as the binding moiety to engage the cereblon E3 ligase complex, and a derivetive of inobrodib (CCS1477) named QC-125 to engage the target proteins.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
compound 19 [PMID: 38316017] |
Database Links ![]() |
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GtoPdb PubChem SID | 491299925 |
PubChem CID | 170836196 |
Search Google for chemical match using the InChIKey | OCWNROZULZWRQM-NWDJCJOJSA-N |
Search Google for chemicals with the same backbone | OCWNROZULZWRQM |
UniChem Compound Search for chemical match using the InChIKey | OCWNROZULZWRQM-NWDJCJOJSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | OCWNROZULZWRQM-NWDJCJOJSA-N |