narceine   Click here for help

GtoPdb Ligand ID: 13150

Synonyms: narcein
Compound class: Natural product or derivative
Comment: Narceine is one of a host of opioid-related alkaloid phytochemicals found in opium poppies. It has opioid-like narcotic and analgesic effects, as well as antitussive properties.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 103.76
Molecular weight 445.46
XLogP 1.15
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN(C)CCC1=C(CC(=O)C2=CC=C(C(=C2C(=O)O)OC)OC)C(=C3C(=C1)OCO3)OC
Isomeric SMILES CN(C)CCC1=CC2=C(C(=C1CC(=O)C3=C(C(=C(C=C3)OC)OC)C(=O)O)OC)OCO2
InChI InChI=1S/C23H27NO8/c1-24(2)9-8-13-10-18-22(32-12-31-18)20(29-4)15(13)11-16(25)14-6-7-17(28-3)21(30-5)19(14)23(26)27/h6-7,10H,8-9,11-12H2,1-5H3,(H,26,27)
InChI Key DEXMFYZAHXMZNM-UHFFFAOYSA-N
Classification Click here for help
Compound class Natural product or derivative
IUPAC Name Click here for help
6-[2-[6-[2-(dimethylamino)ethyl]-4-methoxy-1,3-benzodioxol-5-yl]acetyl]-2,3-dimethoxybenzoic acid
Synonyms Click here for help
narcein
Database Links Click here for help
BindingDB Ligand 50480327
ChEBI CHEBI:7480
ChEMBL Ligand CHEMBL486305
GtoPdb PubChem SID 491299932
PubChem CID 8564
Search Google for chemical match using the InChIKey DEXMFYZAHXMZNM-UHFFFAOYSA-N
Search Google for chemicals with the same backbone DEXMFYZAHXMZNM
UniChem Compound Search for chemical match using the InChIKey DEXMFYZAHXMZNM-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey DEXMFYZAHXMZNM-UHFFFAOYSA-N