rilmenidine   Click here for help

GtoPdb Ligand ID: 13356

Synonyms: Albarel® | S-3341 | S-3341-3 | S3341
Approved drug
rilmenidine is an approved drug
Compound class: Synthetic organic
Comment: Rilmenidine is an oxazoline compound, that is reported to exhibit selectivity for I1 imidazoline receptors (binding sites) compared to cerebral α2-adrenoceptors [1-3].

rilmenidine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 33.62
Molecular weight 180.25
XLogP 1.65
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1CC1C(C2CC2)NC3=NCCO3
Isomeric SMILES C1CC1C(C2CC2)NC3=NCCO3
InChI InChI=1S/C10H16N2O/c1-2-7(1)9(8-3-4-8)12-10-11-5-6-13-10/h7-9H,1-6H2,(H,11,12)
InChI Key CQXADFVORZEARL-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Bousquet P. (2001)
I1 receptors, cardiovascular function, and metabolism.
Am J Hypertens, 14 (11 Pt 2): 317S-321S. [PMID:11721890]
2. Bousquet P, Hudson A, García-Sevilla JA, Li JX. (2020)
Imidazoline Receptor System: The Past, the Present, and the Future.
Pharmacol Rev, 72 (1): 50-79. [PMID:31819014]
3. Gomez RE, Ernsberger P, Feinland G, Reis DJ. (1991)
Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area.
Eur J Pharmacol, 195 (2): 181-91. [PMID:1651861]
4. Nikolic K, Filipic S, Agbaba D. (2008)
QSAR study of imidazoline antihypertensive drugs.
Bioorg Med Chem, 16 (15): 7134-40. [PMID:18621536]