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marstacimab   Click here for help

GtoPdb Ligand ID: 13403

Synonyms: Hympavzi® | marstacimab-hncq
Approved drug
marstacimab is an approved drug (EMA & FDA (2024))
Compound class: Antibody
Comment: Marstacimab (PF-06741086) is a monoclonal antibody that targets tissue factor pathway inhibitor (TFPI) [4]. The antibody blocks the inhibitory effect of TFPI on the FVIIa-TF complex interaction with coagulation factor Xa. This mechanism is proposed to increase coagulation activity of both the intrinsic and extrinsic coagulation pathways, for example in patients with severe haemophilia A or B.
Classification Click here for help
Compound class Antibody
Approved drug? Yes. EU EMA (2024)  |  US FDA (2024)
International Nonproprietary Names Click here for help
INN number INN
10789 marstacimab
Synonyms Click here for help
Hympavzi® | marstacimab-hncq
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 852
Other databases
GtoPdb PubChem SID 496703373
Search PubMed clinical trials marstacimab
Search PubMed titles marstacimab
Search PubMed titles/abstracts marstacimab