Synonyms: compound C [PMID: 38963839]
Compound class:
Synthetic organic
Comment: dWIZ-1 is a molecular glue class molecule that targets WIZ transcription factor protein for degradation via the CRBN E3 ubiquitin ligase/proteasome pathway [1]. Despite structural similarities with lenalidomide, dWIZ-1 does not promote degradation of the known lenalidomide targets IKZF1 (Ikaros) and casein kinase 1α.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
3-[6-[(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione |
Synonyms ![]() |
compound C [PMID: 38963839] |
Database Links ![]() |
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GtoPdb PubChem SID | 500839850 |
PubChem CID | 156500586 |
Search Google for chemical match using the InChIKey | FVZCFUKXGUUDBQ-QSFPRURJSA-N |
Search Google for chemicals with the same backbone | FVZCFUKXGUUDBQ |
UniChem Compound Search for chemical match using the InChIKey | FVZCFUKXGUUDBQ-QSFPRURJSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | FVZCFUKXGUUDBQ-QSFPRURJSA-N |