dWIZ-1   Click here for help

GtoPdb Ligand ID: 13440

Synonyms: compound C [PMID: 38963839]
Compound class: Synthetic organic
Comment: dWIZ-1 is a molecular glue class molecule that targets WIZ transcription factor protein for degradation via the CRBN E3 ubiquitin ligase/proteasome pathway [1]. Despite structural similarities with lenalidomide, dWIZ-1 does not promote degradation of the known lenalidomide targets IKZF1 (Ikaros) and casein kinase 1α.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.95
Molecular weight 399.48
XLogP 0.92
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

SMILES / InChI / InChIKey
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Canonical SMILES CCN1CCCC[C@@H]1[C@@H](C)OC2=CC=C3C(=C2)CN(C4CCC(=O)NC4=O)C3=O
Isomeric SMILES CCN1CCCC[C@@H]1[C@@H](C)OC2=CC3=C(C=C2)C(=O)N(C3)C4CCC(=O)NC4=O
InChI InChI=1S/C22H29N3O4/c1-3-24-11-5-4-6-18(24)14(2)29-16-7-8-17-15(12-16)13-25(22(17)28)19-9-10-20(26)23-21(19)27/h7-8,12,14,18-19H,3-6,9-11,13H2,1-2H3,(H,23,26,27)/t14-,18-,19?/m1/s1
InChI Key FVZCFUKXGUUDBQ-QSFPRURJSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
IUPAC Name Click here for help
3-[6-[(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
Synonyms Click here for help
compound C [PMID: 38963839]
Database Links Click here for help
GtoPdb PubChem SID 500839850
PubChem CID 156500586
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UniChem Connectivity Search for chemical match using the InChIKey FVZCFUKXGUUDBQ-QSFPRURJSA-N