Synonyms: ARV393 | compound 81 [WO2022221673A1]
Compound class:
Synthetic organic
Comment: ARV-393 is an orally active PROTAC that promotes degradation of the BCL6 transcription repressor protein. A lenalidomide derived moiety promotes formation of a ternary complex of the PROTAC, target protein and the E3 ligase cereblon to induce ubiquitination and degradation. The structure shown here has (1r,3r) configuration around the cyclobutoxy group, as indicated for compound 81 in Arvinas' patent WO2022221673A [1]. We will update this entry whenever ARV-393's chemical structure is formally disclosed.
BCL6 is a transcriptional repressor and major driver of B-cell lymphomas. Reducing BCL6 activity or abundance are proposed as mechanisms to treat advanced B-cell malignancies such as non-Hodgkin's lymphoma. |
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
Synonyms ![]() |
ARV393 | compound 81 [WO2022221673A1] |
Database Links ![]() |
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GtoPdb PubChem SID | 500839870 |
PubChem CID | 166077922 |
Search Google for chemical match using the InChIKey | ZOGOEUHUEFKKTD-VVDHFOCHSA-N |
Search Google for chemicals with the same backbone | ZOGOEUHUEFKKTD |
UniChem Compound Search for chemical match using the InChIKey | ZOGOEUHUEFKKTD-VVDHFOCHSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | ZOGOEUHUEFKKTD-VVDHFOCHSA-N |